AMD's Eyefinity broke my multi-display configuration

Radeon software is $@$* for multiple displays.

I suggest uninstalling. Using a registry cleaner and removing ANYTHING related to AMD. Use an driver uninstall utility like DDU.

Then, install everything all over again.

Once you get everything all installed fresh and have all three monitors working (not with Eyefinity) - open up Radeon, go to Eyefinity, Advanced Setup. When that window open up there is a "Presets" section at the top left - create a preset for your current configuration. After you create that preset - create your eyefinity setup. Once Eyefinity is setup correctly go to the same location and create a preset for that.

Once this is done you can go to that same location and choose the preset you desire. That should work. The old versions of Radeon had a way to create a shortcut in the toolbar radeon software so you could easily swap presets. It was still a HUGE pain to get the setups correct. But, once you did it worked pretty well. Now, it is just a huge buggy mess to do this.