Why are various audio plug-ins disabled after changing I/O board?

Diagnosed a failed I/O board on a late 2013 Mac Pro, preventing machine from powering on - swapped out with known good I/O board, this resolved the issue. While the machine was disassembled I removed the internal drive and looked at the data using an external enclosure, mounting on a separate machine. I work at a repair shop so we did try a few other things before discovering the I/O board issue (swapped power supply and interconnect board).

Once the failed I/O board was discovered to be the cause of the issue, we reassembled the machine with a new I/O board and all of the other original components. It now powers on and boots into the user account successfully. I just found out that all of the users audio plugins for various music editing software are now disabled - they are seeing the machine as an unrecognized/unlicensed machine. Is this something that could be caused by the disassembly and reassembly process I performed? Thanks!