I cut the cables to the "back" and "recent apps" buttons. They aren't as sensitive anymore, but fortunately they still work. I also ripped some of the foil on the back of the screen, but I haven't noticed any negative effects from that.
I replaced my midframe, but I cut the cables to the back and menu buttons. I also ripped some of the foil on the back of my screen, but that didn't seem to hurt anything.