Why don't my usb ports not working?

The mouse that was in it died and now all the usb ports don't work in windows UT they do in bios the died one exempt. I tried a pci ether net adapter but it died when I plugged the died mouse in it. This happens before with another mouse on another pc. I think it's caused by the mouses still getting power from the pc when Off i know they get power because the lights inside turn on when plug in then stay on . The mouses work in bios but not when windows turns on. And as I said no usb ports work when windows turns on.

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Have you tried any other USB device to see if it works. e.g a keyboard? What is your PC make and model, if generic what is your motherboard make and model? What OS is installed?