Why is my new screen not responding properly?

I followed the repair guide for replacing the screen to the Letter. Everything went together perfectly without any issues. Now that everything is put together my touch screen that I replaced is not responding properly. Some spots on the screen don't respond to touch at all while other parts are so sensitive it acts on its own accord, like an extra hand id pushing random thhings on the screen. I've gone over the instructions again and again but I cant figure out whats gone wrong.